Comparing different antiemetic regimens for chemotherapy induced nausea and vomiting

Background: Chemotherapy Induced Nausea and Vomiting (CINV) is a major problem for all cancer patients. 5-hydroxytryptamine 3 (5-HT3)-receptor antagonists or serotonin antagonists used along with dexamethasone is the most widely used antiemetic regimen in chemotherapy. But the best drug of the different serotonin antagonists, which is both efficacious and economic, remains a matter of debate. Aims & Objectives: To compare the relative efficacies and safeties of ondansetron, granisetron and palonosetron, when used along with equal dose of dexamethasone, in