ANTIEMETIC PROPHYLAXIS WITH GRANISETR ON, OND ANSETR ON AND METOCLOPRAMIDE IN LAPAROSCOPIC CHOLEC YSTECTOM Y: A COMP ARISON

Introduction : ostoperative nausea and vomiting (PONV) is the most unpleasant and distressing consequence during laproscopic cholecystectomy. This study aims to evaluate and compare the efficacy patient acceptance and side effects of granisetron, ondansetron and metoclopramide as prophylactic antiemetic for laproscopic cholecystectomy. Material and Method : 75 patients of ASA grade I and II in the age group 20-60 yrs undergoing laproscopic cholecystectomy under GA were randomly assigned in a double blind manner into 3 equal groups. Group A received 10mg Metoclopramide, Group B received 4mg ondansetron, Group C received 3 mg granisetron. All the drugs were given through slow intravenous injection diluted in saline over 5-10 min. before induction of anaesthesia. Episode of nausea and vomiting were recorded in the first 24 hours post operatively at the intervals of 0-2, 2-6, 6-12,12-24 hrs. Pain was assessed by visual analog scale (VAS) 0-10. Patient satisfaction with the study medication was assessed using a five point scale, 24 hours after the end of drug administration . The safety of study drugs were assessed by monitoring adverse effects throughout the 24 hour period. All the observation were compiled and statistically analyzed by one way- ANO VA, chi square test using (SPSS 6.0). Results : Among 75 patients, 65 were female and 10 were male (Table:2). Patients in all three groups were statistically comparable . As prophylactic antiemetic granisetron was more significantly efficacious than ondansetron and metoclopramide in between 2-12 hours . Similar result was seen in the satisfaction score. There was no statistically difference in VAS pain score. There were no major adverse effect observed in 24 hrs post-operative period. Common minor adverse effect was dizziness and mild constipation. Conclusion : he results of our study revealed that in the management of PONV , Granisetron was more effective than Ondansetron and Metoclopramide. Therefore Granisetron is more effective drug for controlling post operative nausea and vomiting.