GENOTOXIC AND ANTIPROLIFERATIVE EFFECTS OF THREE NEWLY SYNTHESIZED AMINOPHOSPHONIC ACIDS

ABSTRACT. Aminophosphonic acids are analogs of amino acids where the carboxylic group is substituted with a phosphonic group P(O)(OH)2. A large part of the present research of aminophosphonic acids and their derivatives is focused on their herbicide, antiviral and antitumor activity. This report refers to the investigation of genotoxic and antiproliferative effect of newly synthesized aminophosphonic acids. For the cytogenetical investigation male and female C57Bl mice were administered i.p. with КТ-2, KT-3, KT-4 at doses of 10mg/kg and 100mg/kg. Mitomycin C (Kyowa) 3.5 mg/kg was used as a positive control. Animals injected with 0.9 % NaCl were used as a negative control. The clastogenic and antiproliferative effects of newly synthesized original aminophosphonic acids were investigated for the first time. The studied compounds do not possess clearly expressed relationship “dose-effect ” in their clastogenic effects, as this property is specific for the alkylating agents. Comparatively low percentage of bone marrow metaphases with chromosome aberrations and the lack of