COMPARATIVE ANTIMICROBIAL STUDY BETWEEN ANDROGRAPHIS PANICULATA AND AZADIRACHAT INDICA

In vitro anti-microbial efficacy of dried seed extract of Azadirachat indica and dried leaves of Andrographis paniculata was assessed by agar cup plate method against four micro organisms; Proteus vulgaris, Staphylococcus aureus, Pseudomonas aeruginosa and E. coli. Results of present investigation indicates that the methanolic extract of Andrographis paniculata and n-hexane extract of Azadirachta indica producing a significant (p< 0.05) antimicrobial activity. Out of two plants the leaves extract of Andrographis paniculata possess better antimicrobial properties than Azadirachta indica. Hence Andrographis paniculata will be the better choice for treatment of different pathologic conditions associated with above microbes. Andrographolide is the major active constituent of Andrographis paniculata which may be responsible for antimicrobial activity.