The Effect of Different Doses of Lead on the Mouse Hepatocyte

Background: In a number of studies, lead is playing a role in damaging process of liver cells. The objective of this study is to gain more understanding about the correlation between certain doses of lead and the changes that may occur in the liver cells. Material and methods: The study was conducted on mice, which were divided into four groups of six mice each. Group I received tap water during the entire period of experimentation (30 days), group II, group III and group IV were received 10mg, 20mg and 30mg/kg body weight lead as PbO2 Consecutively (orally and daily). Sections of livers were made and examined by light microscope. Results: Lead affected liver cells (hepatocytes) in mice under certain doses. Group III and group IV animals which received 20mg and 30mg/kg body weight lead as PbO2 Consecutively showed various degrees of degenerative changes in the hepatocytes, such as increased size and dark appearance of the cytoplasm , increased size of the sinusoids. The degree of these changes was more abundant in liver cells of high dose group in comparison with the changes in liver cells of moderate dose group, whereas none of these changes were present in both group I (controls) and group II (low dose group) which received tap water and 10mg /kg body weight lead consecutively. Conclusion: Certain doses of lead could cause damages to the liver cells. نارئفلل ةيدبكلا ايلاخلا ىلع صاصرلا نم ةفلتخم تاعرج ريثأت