Evaluation of the Anti-Diabetic Activity of Glibenclamide in Combination with Ginger in Streptozotocin Induced Diabetes

Diabetes is a common and very prevalent disease and a major health problem worldwide. It has been reported to be the major cause of blindness, kidney failure, lower-extremity amputation cardiovascular diseases and premature mortality. Diabetes has increasing cases in rural and poor populations throughout the world. The possibility of its management by the oral administration of hypoglycemic agents has stimulated great research interest in over the years. Considering that diabetes mellitus is a heterogeneous disorder with multiple causes, the combination of therapeutic agents aimed at specific patho-biological pathways of diabetes and its complications may result in a better and more effective management of this disorder. The present study was conducted to evaluate the anti-diabetic activity of Glibenclamide in combination with Ginger. Diabetes was induced by administration of Streptozotocin (i.p 65 mg/Kg). Biochemical parameters were evaluated in the study. When Glibenclamide is used in combination with Ginger, even at sub therapeutic level of Glibenclamide showed similar effects as that of therapeutic dose of Glibenclamide.