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Ceftaroline Activity When Tested Against Respiratory Tract Infection Pathogens Isolated From USA Medical Centers in 2009

Helio Silva Sader

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Abstract

• Ceftaroline activity against M. catarrhalis isolates (MIC 90 , 0.12 µg/mL) was 4- and 16-fold greater than ceftriaxone (MIC 90 , 0.5 µg/mL) and cefuroxime (MIC 90 , 2 µg/mL), respectively. All comparators tested demonstrated excellent susceptibility rates ≥99.5%, except for trimethoprim/sulfamethoxazole (92.6%; Table 2) • Ceftaroline was active against MRSA (MIC 50/90 , 0.5/1 µg/mL) and methicillin-susceptible S. aureus (MSSA; MIC 50/90 , 0.25/0.25 µg/mL) from respiratory tract infections. 98.7% of S. aureus isolates were inhibited by ceftaroline at ≤1 µg/mL (Tables 1 and 3)

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What this paper is about

• Ceftaroline activity against M. catarrhalis isolates (MIC 90 , 0.12 µg/mL) was 4- and 16-fold greater than ceftriaxone (MIC 90 , 0.5 µg/mL) and cefuroxime (MIC 90 , 2 µg/mL), respectively. All comparators tested demonstrated excellent susceptibility rates ≥99.5%, except for trimethoprim/sulfamethoxazole (92.6%; Table 2) • Ceftaroline was active against MRSA (MIC 50/90 , 0.5/1 µg/mL) and methicillin-susceptible S. aureus (MSSA; MIC 50/90 , 0.25/0.25 µg/mL) from respiratory tract infections. 98.7% of S. aureus isolates were inhibited by ceftaroline at ≤1 µg/mL (Tables 1 and 3)

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Available abstract

• Ceftaroline activity against M. catarrhalis isolates (MIC 90 , 0.12 µg/mL) was 4- and 16-fold greater than ceftriaxone (MIC 90 , 0.5 µg/mL) and cefuroxime (MIC 90 , 2 µg/mL), respectively. All comparators tested demonstrated excellent susceptibility rates ≥99.5%, except for trimethoprim/sulfamethoxazole (92.6%; Table 2) • Ceftaroline was active against MRSA (MIC 50/90 , 0.5/1 µg/mL) and methicillin-susceptible S. aureus (MSSA; MIC 50/90 , 0.25/0.25 µg/mL) from respiratory tract infections. 98.7% of S. aureus isolates were inhibited by ceftaroline at ≤1 µg/mL (Tables 1 and 3)

Key concepts: Ceftriaxone, Microbiology, Cefuroxime, Trimethoprim, Medicine, Minimum inhibitory concentration, Sulfamethoxazole, Respiratory tract infections

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