Effects of Psidium guajava Aqueous Extract on Testosterone and Serum Lipid Profile of Albino Rats

The effect of oral administration of aqueous extract of Psidium guajava leaves on testosterone and some serum lipid parameters in rats at a dose of 250 mg/kg and 500 mg/kg body weight has been investigated. The extract significantly reduced (p<0.05) total cholesterol concentration, triglycerides and HDL-cholesterol concentration in the serum while it showed no significant effect on serum LDL-cholesterol concentration at all doses administered when compared with control. The recorded data in the present study showed that the testosterone value reduced significantly (p<0.05) from control value (170.62±1.3 ng/dL, 130.94±0.98 ng/dL and 43.80±1.16 ng/dL for control and treated groups respectively) suggesting that the extract may have beneficial effect on serum cholesterol concentration and triglycerides reduction. The reduction in serum testosterone levels indicate significant contraceptive efficacy of P. guajava aqueous extract as a sizable reduction in weight of organs like testis, epididymis, prostate and seminal vesicle.