ScholarLens Back to search
2009•Journal of Al-Nahrain University-ScienceOpen access

COLORIMETRIC ASSAY OF ASPIRIN USING MODIFIED METHOD

Maadh Qusay Abdulkadir, May Mohammed Jawad Al-Mudhafar, Amera Abbas Mohammed, Suha K. Alzahawie

Open full text 2 citations

Abstract

In this research, we did this qualitative and quantitative study in order to improve the assay of aspirin colorimetrically using visible spectrophotometer.This method depends on aqueous hydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violet colored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximum absorption at 530nm.This procedure was applied to determine the purity of aspirin powder and tablet.The results were approximately comparative so that the linearity was observed in the high value of both correlation coefficient (R = 0.998) and Determination Coefficient or Linearity (R 2 = 0.996) while the molar absorpitivity was 1.3×10 3 mole -1 .L.cm -1 .This improvement cancelled the acid or base aided hydrolysis which is widely used during aspirin assay.This method could be also applied to salicylic acid.

Open-access reader

About this research paper

What this paper is about

In this research, we did this qualitative and quantitative study in order to improve the assay of aspirin colorimetrically using visible spectrophotometer.This method depends on aqueous hydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violet colored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximum absorption at 530nm.This procedure was applied to determine the purity of aspirin powder and tablet.The results were approximately comparative so that the linearity was observed in the high value of both correlation coefficient (R = 0.998) and Determination Coefficient or Linearity (R 2 = 0.996) while the molar absorpitivity was 1.3×10 3 mole -1 .L.cm -1 .This improvement cancelled the acid or base aided hydrolysis which is widely used during aspirin assay.This method could be also applied to salicylic acid.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

In this research, we did this qualitative and quantitative study in order to improve the assay of aspirin colorimetrically using visible spectrophotometer.This method depends on aqueous hydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violet colored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximum absorption at 530nm.This procedure was applied to determine the purity of aspirin powder and tablet.The results were approximately comparative so that the linearity was observed in the high value of both correlation coefficient (R = 0.998) and Determination Coefficient or Linearity (R 2 = 0.996) while the molar absorpitivity was 1.3×10 3 mole -1 .L.cm -1 .This improvement cancelled the acid or base aided hydrolysis which is widely used during aspirin assay.This method could be also applied to salicylic acid.

Key concepts: Salicylic acid, Aspirin, Hydrolysis, Chemistry, Chromatography, Correlation coefficient, Ferric, Chloroform

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
COLORIMETRIC ASSAY OF ASPIRIN USING MODIFIED METHOD — Research Paper | ScholarLens