PREPARATION AND CHARACTERIZATION OF SPRAY DRIED MICROPARTICLE AND CHILLED SPRAY DRIED PARTICLE OF KETOPROFEN BY SPRAY DRYING METHOD

Ketoprofen, an anti-inflammatory drug, exhibits poor water solubility and flow properties, poor dissolution and poor wetting. Consequently, the aim of this study was to improve the dissolution of ketoprofen. Microparticles containing ketoprofen were produced by spray drying and spray chilling technology to enhance dissolution rate. The prepared formulations were evaluated for in vitro dissolution and solubility. The produced drug particles were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC), x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Dissolution profile of the spray dried micropartical was compared with chilled spray micropartical, pure sample and recrystallized sample. Spray dried micropartical exhibited decreased crystallinity, but for spray chilled particles there was evidence of polymorphic changes in the drug and improved micromeritic properties. The dissolution of the Spray dried micropartical was improved compared with spray chilling micropartical, recrystallized and pure sample. Consequently, it is believed that spray drying of Ketoprofen is a useful tool to improve wettability, solubility and hence the dissolution behavior of poorly water soluble drugs, in contrast to spray chilling technique.