SYNTHESIS OF SOME NOVEL QUINAZOLIN-4(3H)-ONES AS POTENT ANTIMICROBIAL AGENTS

Quinazolin-4(3H)-ones are the most important class of heterocyclic compounds. A number of substituted quinazolin-4(3H)-ones are known for their biological importance like antimicrobial, anti-inflammatory, analgesic etc. The present investigation comprises study on the synthesis and antimicrobial activity of some novel quinazolin-4(3H)-one derivatives. In the current investigation, anthranillic acid was condensed with acetic anhydride to give 2-methyl-3,1-benzoxazin-4-one which on reaction with paminoacetophenone produces 3-(4-acetophenyl)-2-methylquinazolin-4(3H)-one.This compound on further reaction with KCN, glacial acetic acid, ethanol and different substituted arylamines gave 2-substituted arylamino-2-(4-(2-methyl-4-oxoquinazolin3(4H)-yl)phenyl)propanenitriles. Later these compounds on reaction with 95% H 2 SO 4 afforded 2-substituted arylamino-2-(4-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenyl) propanamides. The structure of these compounds have been established on the basis of their analytical and spectral data (IR, 1 HNMR & Mass). These compounds were tested for in-vitro antibacterial activity against B.cereus, S.aureus, E.coli, and antifungal activity against Candida albicans by standard methods. The synthesized compounds have shown moderate to good antibacterial as well as antifungal activity.