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2010•14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010Requires access

ELECTROPHYSIOLOGICAL RECORDINGS USING SPATIALLY ARRANGED MICROELECTRODE PROBES EMBEDDED INTO 3-D NEURONAL CULTURES

Wataru Tonomura, Koichi Shimizu, Satoshi Konishi

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Abstract

This paper presents spatially arranged microelectrode probes to allow electrophysiological recordings inside 3–D neuronal cultures. Out–of–plane microelectrode probes standing on a substrate have gradation in height. Wire– bonding–based probe technology [1] makes it possible to provide the flexible probes. We would understand the dependent alteration of cellular activities caused by the construction process of 3–D artificial neuronal networks, because the developed probes can directly and spatially record cellular activities inside 3–D cell cultures. This paper demonstrates electrophysiological activities inside 3–D neuronal cultures could be successfully recorded using the embedded probes.

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What this paper is about

This paper presents spatially arranged microelectrode probes to allow electrophysiological recordings inside 3–D neuronal cultures. Out–of–plane microelectrode probes standing on a substrate have gradation in height. Wire– bonding–based probe technology [1] makes it possible to provide the flexible probes. We would understand the dependent alteration of cellular activities caused by the construction process of 3–D artificial neuronal networks, because the developed probes can directly and spatially record cellular activities inside 3–D cell cultures. This paper demonstrates electrophysiological activities inside 3–D neuronal cultures could be successfully recorded using the embedded probes.

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OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This paper presents spatially arranged microelectrode probes to allow electrophysiological recordings inside 3–D neuronal cultures. Out–of–plane microelectrode probes standing on a substrate have gradation in height. Wire– bonding–based probe technology [1] makes it possible to provide the flexible probes. We would understand the dependent alteration of cellular activities caused by the construction process of 3–D artificial neuronal networks, because the developed probes can directly and spatially record cellular activities inside 3–D cell cultures. This paper demonstrates electrophysiological activities inside 3–D neuronal cultures could be successfully recorded using the embedded probes.

Key concepts: Microelectrode, Electrophysiology, Multielectrode array, Neuroscience, Chemistry, Biology, Electrode, Physical chemistry

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