2000•Unpublished venueRequires access
effects of polysorbate 20 and polysorbate 80 on liberation of hydrocrotisone from hydr ophilic gels
Maria Szcześniak, Witold Musiał
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Abstract
The process of hydrocortisone release from the hydrogels with the addition of 1% and 3% polysorbate 20 or polysorbate 80, in the presence of 1,2-propylene glycol or PEG 200 has two phases. In the first phase the liberation rates are higher in comparison with the second phase. The second release phase conforms to the first order kinetics. Semiliberation rates in this phase are in the range from 15,67 to 23,50.