2010•Journal of Pharmacy ResearchRequires access

In-vitro antioxidant activity and free radical scavenging potential of roots of Vitex vestita.

V. Sreedhar, L. K. Ravindranath, N. Madanagopal, K. Venugopal, Rajasekhar Komarla Kumarachari, G. H. Reddy

Abstract

The selected plant extracts and known antioxidant ascorbic acid at various concentrations produced dose dependent inhibition of superoxide radicals, hydroxyl radicals, lipid peroxidation, DPPH radical activities. The IC 50 values for superoxide radical with chloroform and methanolic extracts of Vitex trifoliata were found to be 191.41 µg, 249.32 µg. The IC50 values for hydroxyl radical with chloroform and methanolic extracts of Vitex trifoliata were found to be 290.12 µg, 348.50 µg. The IC50 values for inhibition of lipid peroxidation activity with chloroform and methanolic extracts of Vitex trifoliata were found to be 262.30 µg, 310.72 µg. The IC50 values for DPPH radical with chloroform and methanolic extracts of Vitex trifoliata were found to be 122.20 µg, 169.32 µg.

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Key concepts: Vitex, DPPH, Chemistry, Chloroform, Lipid peroxidation, Antioxidant, Ascorbic acid, Hydroxyl radical