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The dihydropyridine-sensitive calcium channel of the skeletal muscle: biochemistry and structure.

Wolfgang Nastainczyk, A. Ludwig, Franz Hofmann

Abstract

The dihydropyridine-sensitive calcium channel of the rabbit skeletal muscle is the first voltage-gated calcium channel which has been purified and biochemically characterized. The alpha 1-subunit, a 165 kDa protein, of the purified dihydropyridine receptor contains all regulatory sites of a L-type calcium channel and the calcium conducting unit. The purpose of this review is to summarize and discuss recent findings on the structure and possible function of the skeletal muscle calcium channel subunits.

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Key concepts: Calcium channel, Dihydropyridine, N-type calcium channel, Skeletal muscle, R-type calcium channel, Calcium, Chemistry, Voltage-dependent calcium channel