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1987•Biological BulletinOpen access

PHARMACOLOGICAL ACTIONS OF THE MARINE TOXINS CIGUATOXIN AND MAITOTOXIN ISOLATED FROM POISONOUS FISH

Yasushi Ohizumi

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Abstract

Ciguatoxin and maitotoxin isolated from poisonous fish and toxic dinoflagellates exhibited a powerful excitatory effect on smooth and cardiac muscle. The ciguatoxin-induced excitatory action is due to an increase in Na+ permeability of tetrodotoxin sensitive Na channels, while the maitotoxin-induced excitatory effect is caused by an increased Ca2+ permeability of the cell membrane.

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What this paper is about

Ciguatoxin and maitotoxin isolated from poisonous fish and toxic dinoflagellates exhibited a powerful excitatory effect on smooth and cardiac muscle. The ciguatoxin-induced excitatory action is due to an increase in Na+ permeability of tetrodotoxin sensitive Na channels, while the maitotoxin-induced excitatory effect is caused by an increased Ca2+ permeability of the cell membrane.

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Available abstract

Ciguatoxin and maitotoxin isolated from poisonous fish and toxic dinoflagellates exhibited a powerful excitatory effect on smooth and cardiac muscle. The ciguatoxin-induced excitatory action is due to an increase in Na+ permeability of tetrodotoxin sensitive Na channels, while the maitotoxin-induced excitatory effect is caused by an increased Ca2+ permeability of the cell membrane.

Key concepts: Ciguatoxin, Tetrodotoxin, Biology, Excitatory postsynaptic potential, Marine toxin, Ciguatera, Fish <Actinopterygii>, Toxin

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PHARMACOLOGICAL ACTIONS OF THE MARINE TOXINS CIGUATOXIN AND MAITOTOXIN ISOLATED FROM POISONOUS FISH — Research Paper | ScholarLens