2011•Journal of Multiple SclerosisRequires access

Neuromyelitis Optica Spectrum Disorders: Diagnostic Issues in Korea

Min Ju-Hong

Abstract

Neuromyelitis optica (NMO) is a CNS demyelinating disorder, characterized by optic neuritis and acute myelitis. A specific autoantibody of NMO, NMO-IgG was recently detected, which resulted in the revision of the diagnostic criteria of NMO, proposed in 1999. The new diagnostic criteria emphasized the long cord lesion over 3 vertebral segments and the presence of NMO-IgG. In addition, with the positivity of NMO-IgG in longitudinal extensive myelitis, recurrent optic neuritis and autoimmune disorders, the spectrum of NMO-related disorders were broadened. The review for NMO spectrum disorders and NMO-IgG will provide a help to understand NMO, this rapidly disabling disease.

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Key concepts: Neuromyelitis optica, Medicine, Optic neuritis, Myelitis, Spectrum disorder, Demyelinating Disorder, Multiple sclerosis, Autoantibody