In-Vitro Activity of Ceftriaxone in Combination with Sulbactam and Tazobactam against Escherichia Coli

The aim of the study was to compare the antimicrobial effect of combination of ceftriaxone/sulbactam and ceftriaxone/tazobactam against Escherichia coli (E. Coli). Isolate of β-lactamase producing E. coli was cultured and their sensitivity tests were done with both combinations using specially prepared antibiotic disks. National Committee for Clinical Laboratory Standards zone diameter criteria was used to measure and evaluate the zones of inhibition. The disks containing the combination of ceftriaxone with tazobactam produced larger zones of inhibition than those containing combination of ceftriaxone with sulbactam. Addition of tazobactam with ceftriaxone adds more to the efficacy of ceftriaxone against E. Coli as compared to the efficacy of ceftriaxone with sulbactam..