2005•Unpublished venueRequires access

Randomized,Double-Blind, Crossover Comparison Between Two Levocetirizine Formulations on Histamine-Induced Cutaneous Response in Healthy Male Human Adult Volunteers

Usharani Pingali, Mur Naidu, T. Ramesh Kumar

Abstract

Cetirizine is a highly efficacious and long acting second generation H1 receptor antagonist indicated for the treatment of allergic diseases. It is a racemate mixture composed of equal amounts of Sand R-enantiomers, and the R-enantioner, levocetirizine, carries the majority of the histamine H1-receptor-blocking activity. Recently, levocetirizine formulation has been introduced in India for the treatment of allergic rhinitis and urticaria. Objective: The aim of this study was to compare the effect of levocetirizine (Indian formulation) versus an international brand of levocetirizine in 12 Usharan-vol5no1 3/8/05 4:37 PM Page 149

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Key concepts: Levocetirizine, Cetirizine, Histamine, Histamine H1 receptor, Medicine, Crossover study, Pharmacology, Antagonist