ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF VITIS VINIFERA LEAVES

Summary The methanolic extract of Vitis vinifera leaves at 100, 200 and 400 mg/kg body weight were evaluated for anti-inflammatory and analgesic activities in rats and mice. Anti-inflammatory activity was studied by using carrageenan and histamine induced oedema right hind paw volume while the analgesic effect was evaluated using formalin-induced pain and tail flick nociception response. Methanolic extract showed significant (p<0.01) and dose dependent analgesic and anti-inflammatory activity in comparison to control group. The potential analgesic and anti-inflammatory by methanolic extract was comparatively less than that of diclofenac (10 mg/kg p.o.). Methanolic extract did not show any toxicity and mortality up to maximum dose of 2 gm/kg of body weight. Preliminary phytochemical screening revealed the presence of flavonoids, saponins and carbohydrate, tannins and phenolic compounds in methanolic extract. Thus it could be concluded that methanolic extract Vitis vinifera possess significant analgesic and anti-inflammatory activity.