Evaluation of anticandidial effect of antifungal drugs against Candida isolates.

In the present study, we obtained 150 Candida strains which were originally isolated from various clinical specimens from different health institutions and diagnostic laboratories. To identify the various Candida species from the 150 Candida strains we applied three different techniques. We could able to identify the different Candida species from the 150 Candida strains which were originally isolated from various clinical specimens ie, Candida albicans (75%), Candida dubliniensis (15%), Candida tropicalis (9%), Candida kruseii (8%). Among all the Candida species Candida albicans was the predominant (75%) Candida species identified followed by Candida dubliniensis (15%), Candida tropicalis (9%) and Candida kruseii (8%). Among the 4 different Candida morphotypes, Candida albicans yielded 3 different Candida morphotypes which 254, 534 and 554. Candida morphotypes 554 was found to be the predominant Candida morphotypes we could able to record and also associated with vaginitis among non diabetic women. All 4 different Candida morphotypes were subjected to the antifungal susceptibility test to 6 different antifungal drugs ie, ketoconazole, nystatin, fluconazole, clotrimazole, amphotericin-B and itraconazole by disc diffusion technique. All these 4 different Candida morphotypes had shown different types of sensitivity and resistant pattern towards these 6 antifungal drugs, among which we good able to record the Candida morphotypes 254 & 554 had shown the maximum resistant towards the antifungal drug clotrimazole. Finally from our short term research on “The Candida morphotypes associated with certain clinical infections and its antifungal susceptibility pattern”. We could able to note and conclude that certain Candida morphotypes are associated with certain infection and also showing significant percentage of antifungal resistance. To find out more details, this field of research need future extensive research and we can suggest that the future study related to this field can be under taken by the other researchers.