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Different Cell Susceptibility to Epstein-Barr Virus Infection in a Patient with X-Linked Lymphoproliferative Syndrome

Motohiko Okano, Geoffrey M. Thiele, Thomas G. Gross, Jack R. Davis, David T. Purtilo

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Abstract

Epstein-Barr virus (EBV) is an ubiquitous B lymphotropic virus which causes infectious mononucleosis (IM) and is associated with human malignancies such as Burkitt’s lymphoma and nasopharyngeal carcinoma (1). Recently, EBV-induced lymphoproliferation and lymphoma have been reported in patients with primary or secondary immunodeficiency (1). Depending on the type and degree of immunodeficiency, and timing of the EBV infection, individuals appear to develop a variety of life-threatening lymphoproliferative diseases. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

About this research paper

What this paper is about

Epstein-Barr virus (EBV) is an ubiquitous B lymphotropic virus which causes infectious mononucleosis (IM) and is associated with human malignancies such as Burkitt’s lymphoma and nasopharyngeal carcinoma (1). Recently, EBV-induced lymphoproliferation and lymphoma have been reported in patients with primary or secondary immunodeficiency (1). Depending on the type and degree of immunodeficiency, and timing of the EBV infection, individuals appear to develop a variety of life-threatening lymphoproliferative diseases. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Why it matters

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Key contribution

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Method / approach

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Main findings

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Available abstract

Epstein-Barr virus (EBV) is an ubiquitous B lymphotropic virus which causes infectious mononucleosis (IM) and is associated with human malignancies such as Burkitt’s lymphoma and nasopharyngeal carcinoma (1). Recently, EBV-induced lymphoproliferation and lymphoma have been reported in patients with primary or secondary immunodeficiency (1). Depending on the type and degree of immunodeficiency, and timing of the EBV infection, individuals appear to develop a variety of life-threatening lymphoproliferative diseases. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Key concepts: Mononucleosis, Nasopharyngeal carcinoma, Lymphoma, Epstein–Barr virus, Virus, Virology, Lymphoproliferative disorders, Immunology

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Different Cell Susceptibility to Epstein-Barr Virus Infection in a Patient with X-Linked Lymphoproliferative Syndrome — Research Paper | ScholarLens