2012•亚洲传统医药Requires access
Protective effect of the roots of Capparis sepiaria Linn. (Himsra) on carbon tetrachloride-induced hepatotoxicity
Varadharajan Madhavan, Anita Murali, Sunkam Yoganarsimhan, Ajay Shankar Pandey
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Abstract
Capparis sepiaria L. is an important drug used in Ayurvedic medicine. In the present study extracts of the roots of C. sepiaria were evaluated for their hepatoprotective potential on carbon tetrachloride (CCl4)-induced hepatotoxicity in albino Wistar rats. The extent of hepatoprotection was evaluated by estimating the serum levels of hepatic transaminases (SGPT and SGOT), alkaline phosphatase (ALP), total protein (TP), and bilirubin (total and direct). Aqueous and ethanol extracts significantly reduced the increased liver weight as well as the serum levels of SGPT, SGOT, ALP, and bilirubin and normalized the reduced serum protein levels in the treated rats as supported by histopathological studies. The extracts were also subjected to preliminary organic analysis and chromatographic studies including an HPTLC finger print profile. The results obtained indicate that the roots of C. sepiaria have a significant hepatoprotective effect on CCl 4-induced hepatotoxicity.