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PROTECTIVE EFFECT OF CAESALPENIA BONDUCELLA L. LEAF AGAINST ACETAMINOPHEN- INDUCED LIVER DAMAGE IN WISTAR RATS

Javed Akhtar Ansari, Mateen Sayyed, Annamalai Nagar

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Abstract

In the present study, methanol extract of Ceasalpinia bonducella leaf was evaluated against acetaminophen-induced liver damage in Wistar rats for its hepatoprotection action. Animals were divided into 5 groups of six rats each. Oral administration of CB (800 mg/kg) along with Acetaminophen (AA; 2.5 g/kg) showed a significant increase in serum enzyme AST, ALT, Total Bilirubin, Direct Bilirubin and Alkaline Phosphatase levels with a decrease in Total Protein levels (P<0.01). The results were similar to Silymarin (SL), a standard hepatoprotective drug. The present study reveals that the administration of CB can be beneficial for the suppression of liver toxicity. Based on present findings, it can be concluded that methanol extract of Caesalpenia bonducella L. protects the liver from acetaminophen-induced liver damage.

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What this paper is about

In the present study, methanol extract of Ceasalpinia bonducella leaf was evaluated against acetaminophen-induced liver damage in Wistar rats for its hepatoprotection action. Animals were divided into 5 groups of six rats each. Oral administration of CB (800 mg/kg) along with Acetaminophen (AA; 2.5 g/kg) showed a significant increase in serum enzyme AST, ALT, Total Bilirubin, Direct Bilirubin and Alkaline Phosphatase levels with a decrease in Total Protein levels (P<0.01). The results were similar to Silymarin (SL), a standard hepatoprotective drug. The present study reveals that the administration of CB can be beneficial for the suppression of liver toxicity. Based on present findings, it can be concluded that methanol extract of Caesalpenia bonducella L. protects the liver from acetaminophen-induced liver damage.

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Available abstract

In the present study, methanol extract of Ceasalpinia bonducella leaf was evaluated against acetaminophen-induced liver damage in Wistar rats for its hepatoprotection action. Animals were divided into 5 groups of six rats each. Oral administration of CB (800 mg/kg) along with Acetaminophen (AA; 2.5 g/kg) showed a significant increase in serum enzyme AST, ALT, Total Bilirubin, Direct Bilirubin and Alkaline Phosphatase levels with a decrease in Total Protein levels (P<0.01). The results were similar to Silymarin (SL), a standard hepatoprotective drug. The present study reveals that the administration of CB can be beneficial for the suppression of liver toxicity. Based on present findings, it can be concluded that methanol extract of Caesalpenia bonducella L. protects the liver from acetaminophen-induced liver damage.

Key concepts: Acetaminophen, Hepatoprotection, Bilirubin, Alkaline phosphatase, Toxicity, Liver damage, Liver toxicity, Pharmacology

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PROTECTIVE EFFECT OF CAESALPENIA BONDUCELLA L. LEAF AGAINST ACETAMINOPHEN- INDUCED LIVER DAMAGE IN WISTAR RATS — Research Paper | ScholarLens