2015•VirusesOpen access

Chikungunya Virus Replication in Salivary Glands of the Mosquito Aedes albopictus

Anubis Vega-Rúa, Christine Schmitt, Isabelle Bonne, Jacomine Krijnse Locker, Anna‐Bella Failloux

Abstract

Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standardized protocol to visualize viral particles in the mosquito salivary glands using transmission electron microscopy. Here we provide direct evidence for CHIKV replication and storage in Ae. albopictus salivary glands.

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Key concepts: Aedes albopictus, Arbovirus, Chikungunya, Virology, Biology, Midgut, Virus, Salivary gland