1992•Alcohol and AlcoholismRequires access

ACETALDEHYDE, ETHANOL AND ACETONE CONCENTRATIONS IN BLOOD OF ALCOHOL-TREATED MICE RECEIVING ALDEHYDE DEHYDROGENASE-LOADED ERYTHROCYTES

Paolino Ninfali, Luigia Rossi, Luciano Baronciani, Bruno Tirillini, C. Ropars, Mauro Magnani

Abstract

Blood levels of acetaldehyde (ACh), ethanol and acetone were investigated in mice treated with ethanol for 6 months and receiving compatible erythrocytes (RBCs) overloaded with aldehyde dehydrogenase (AlDH). Following an acute dose of ethanol, ACh levels were significantly lower in these animals than in alcohol-treated mice receiving AlDH-unloaded RBCs, and were similar to the ACh levels of normal mice. The peak ethanol concentration was higher in normal mice than in both groups of alcohol-treated animals, while acetone concentrations were not significantly different in the three groups of animals.

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Key concepts: Acetaldehyde, Aldehyde dehydrogenase, Ethanol, Acetone, Alcohol dehydrogenase, Alcohol, Chemistry, Biochemistry