2003•Nucleosides Nucleotides & Nucleic AcidsRequires access
Commercial-Scale Synthesis of Protected 2′-Deoxycytidine and Cytidine Nucleosides
K. J. DIVAKAR, Chitra M. Sawant, Y. A. Mulla, Deepak V. Zemse, Sakina M. Sitabkhan, Bruce S. Ross, Yogesh S. Sanghvi
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Abstract
Transformation of 2'-deoxyuridine and uridine analogs to protected 2'-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and suitable for commercial scale-up.