2002•The Journal of Organic ChemistryRequires access
An Effective Procedure for the Acylation of Azaindoles at C-3
Zhongxing Zhang, Zhong Yang, Henry Ν. C. Wong, Juliang Zhu, Nicholas A. Meanwell, John F. Kadow, Tao Wang
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Abstract
Conditions for attachment of acetyl chloride, benzoyl chloride, and chloromethyl oxalate to the 3-position of 4-, 5-, 6-, or 7-azaindoles were explored. Best results were achieved with an excess of AlCl(3) in CH(2)Cl(2) followed by the addition of an acyl chloride at room temperature.