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Lethality of heterozygotes betweent-haplotype complementation groups of mouse: sex-related effect on lethality oft6/tw5heterozygotes

Kathleen B. Bechtol

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Abstract

Summary The various lethalt-haplotypes are divided into several complementation groups defined by lethality oftx/tyheterozygotes, and only partial complementation is usually observed in heterozygotes betweentcomplementation groups. Several effects of thetregion have been found to be preferentially or exclusively detectable in males. This paper describes results showing that the viability oft6/tw5heterozygotes is influenced by the sex of the embryo; female viability is only slightly reduced (viability ratio approximately 0·80), while male viability is far below normal (0·25).

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Summary The various lethalt-haplotypes are divided into several complementation groups defined by lethality oftx/tyheterozygotes, and only partial complementation is usually observed in heterozygotes betweentcomplementation groups. Several effects of thetregion have been found to be preferentially or exclusively detectable in males. This paper describes results showing that the viability oft6/tw5heterozygotes is influenced by the sex of the embryo; female viability is only slightly reduced (viability ratio approximately 0·80), while male viability is far below normal (0·25).

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Summary The various lethalt-haplotypes are divided into several complementation groups defined by lethality oftx/tyheterozygotes, and only partial complementation is usually observed in heterozygotes betweentcomplementation groups. Several effects of thetregion have been found to be preferentially or exclusively detectable in males. This paper describes results showing that the viability oft6/tw5heterozygotes is influenced by the sex of the embryo; female viability is only slightly reduced (viability ratio approximately 0·80), while male viability is far below normal (0·25).

Key concepts: Complementation, Heterozygote advantage, Biology, Genetics, Haplotype, Lethality, Embryo, Allele

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