Hepatoprotective activity of Mimosa pudica leaves against carbontetrachloride induced toxicity.

The methanolic extract of leaves of Mimosa pudica at the dose of 200mg/kg body weight per oral was studied for the hepatoprotective effect using Carbontetrachloride induced liver damage in wistar albino rats. Methanolic extract showed significant (p<0.05) hepatoprotective effect by lowering the serum levels of various biochemical parameters such as serum glutamic oxaloacetate transaminase (SGOT), serum glutamic pyruvates transaminase (SGPT), alkaline phospatase (ALP), total bilirubin (TBL), total cholesterol (CHL) and by increasing the levels of total protein (TPTN) and albumin (ALB), in the selected model. These biochemical observations were inturn confirmed by histopathological examinations of liver sections and are comparable with the standard hepatoprotective drug Silymarin (100mg/kg body weight i.p.) which served as a positive control. The overall experimental results suggests that the biologically active phytoconstituents such as flavonoids, glycosides alkaloids present in the methanolic extract of plant Mimosa pudica, may be responsible for the significant hepatoprotective activity and the results justify the use of Mimosa pudica as a hepatoprotective agent.