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1977•The Journal of Clinical Endocrinology & MetabolismRequires access

Suppression of Thyrotropin (TSH) and Prolactin (PRL) Release by Pyridoxine in Chronic Primary Hypothyroidism

Giuseppe Delitala, Pierpaolo Rovasio, G Lotti

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Abstract

A single iv dose of pyridoxine (V) (300 mg) caused a significant decrease in the concentration of serum thyrotropin (TSH) in 6 patients with primary hypothyroidism. There was no consistent change in serum thyroxine and triiodothyronine concentrations suring the experiment. The serum prolactin (PRL) levels were also suppressed by pyridoxine administration. These findings suggest that pyridoxine inhibits TSH secretion as well PRL by a direct action on the hypothalamus or pituitary gland.

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What this paper is about

A single iv dose of pyridoxine (V) (300 mg) caused a significant decrease in the concentration of serum thyrotropin (TSH) in 6 patients with primary hypothyroidism. There was no consistent change in serum thyroxine and triiodothyronine concentrations suring the experiment. The serum prolactin (PRL) levels were also suppressed by pyridoxine administration. These findings suggest that pyridoxine inhibits TSH secretion as well PRL by a direct action on the hypothalamus or pituitary gland.

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OpenAlex reports 23 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A single iv dose of pyridoxine (V) (300 mg) caused a significant decrease in the concentration of serum thyrotropin (TSH) in 6 patients with primary hypothyroidism. There was no consistent change in serum thyroxine and triiodothyronine concentrations suring the experiment. The serum prolactin (PRL) levels were also suppressed by pyridoxine administration. These findings suggest that pyridoxine inhibits TSH secretion as well PRL by a direct action on the hypothalamus or pituitary gland.

Key concepts: Internal medicine, Endocrinology, Pyridoxine, Prolactin, Triiodothyronine, Thyrotropin-releasing hormone, Hypothalamus, Secretion

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Suppression of Thyrotropin (TSH) and Prolactin (PRL) Release by Pyridoxine in Chronic Primary Hypothyroidism — Research Paper | ScholarLens