1985•Journal of Antimicrobial ChemotherapyRequires access

Effects of clindamycin in combination with rifampicin on clindamycin-susceptible and clindamycin-resistant Staphylococcus aureus

Chatrchai Watanakunakorn

Abstract

The effects of the combination of clindamycin and rifampicin against 21 strains of clindamycin-susceptible and 19 strains of clindamycin-resistant Staphylococcus aureus were studied by the time-kill method. For the clindamycin-susceptible strains, clindamycin prevented the re-growth of Staph. aureus in the presence of rifampicin. For the clindamycin-resistant Staph. aureus strains, indifference was demonstrated against the majority of strains, with only a few strains showing synergism or antagonism.

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Key concepts: Clindamycin, Staphylococcus aureus, Rifampicin, Medicine, Antibiotics, Antimicrobial chemotherapy, Microbiology, Antimicrobial