1988•Clinical and Experimental Pharmacology and PhysiologyRequires access

AN UNUSUAL PHOSPHATIDYLINOSITOL TURNOVER PATHWAY IN NORADRENALINE‐PERFUSED RAT HEARTS

Elizabeth A. Woodcock, A. Ian Smith, Catherine A. Wallace, Les White

Abstract

1. The phosphatidylinositol turnover pathway has been studied in noradrenaline-perfused rat hearts using anion-exchange high performance liquid chromatography. 2. The active calcium-releasing compound inositol-(1,4,5)trisphosphate was detected together with its degradation products inositol-(1,4)bisphosphate and inositol monophosphate. All these products increased in response to noradrenaline stimulation. 3. At noradrenaline perfusion times from 5 s to 20 min there was no appearance of inositol-(1,3,4,5)tetrakisphosphate or its degradation products: inositol-(1,3,4)trisphosphate or inositol-(1,3) and (3,4)bisphosphates. 4. These data suggest the absence of the inositol-(1,4,5)trisphosphate phosphorylation/dephosphorylation pathway in heart.

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Key concepts: Inositol, Dephosphorylation, Phosphatidylinositol, Inositol trisphosphate, Inositol phosphate, Chemistry, Phosphorylation, Calcium