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1976•The Journal of BiochemistryRequires access

Existence of Glucosaminyl Lactosyl Ceramide (Amino CTH-I) in Human Erythrocyte Membranes as a Possible Precursor of Blood Group-Active Glycolipids

Susumu ANDO, Kazuo Kon, Miyoko ISOBE, Yoshitaka Nagai, Tamio Yamakawa

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Abstract

A novel glycolipid containing N-acetylglucosamine (lacto-N-triose II ceramide, Amino CTH-I) was isolated as a minor component from the ceramide trihexoside fraction of human erythrocyte lipids. This glycolipid was purified by column chromatography and preparative high-speed liquid chromatography on Iatrobeads. Its structure was found to be N-acetylglucosaminyl(beta 1-3)galactosyl(beta 1-4)glucosyl-(beta 1-1)ceramide, so it is suggested that it may be a precursor of paragloboside and blood group-active glycolipids.

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What this paper is about

A novel glycolipid containing N-acetylglucosamine (lacto-N-triose II ceramide, Amino CTH-I) was isolated as a minor component from the ceramide trihexoside fraction of human erythrocyte lipids. This glycolipid was purified by column chromatography and preparative high-speed liquid chromatography on Iatrobeads. Its structure was found to be N-acetylglucosaminyl(beta 1-3)galactosyl(beta 1-4)glucosyl-(beta 1-1)ceramide, so it is suggested that it may be a precursor of paragloboside and blood group-active glycolipids.

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Available abstract

A novel glycolipid containing N-acetylglucosamine (lacto-N-triose II ceramide, Amino CTH-I) was isolated as a minor component from the ceramide trihexoside fraction of human erythrocyte lipids. This glycolipid was purified by column chromatography and preparative high-speed liquid chromatography on Iatrobeads. Its structure was found to be N-acetylglucosaminyl(beta 1-3)galactosyl(beta 1-4)glucosyl-(beta 1-1)ceramide, so it is suggested that it may be a precursor of paragloboside and blood group-active glycolipids.

Key concepts: Glycolipid, Ceramide, Membrane, Human blood, Chemistry, Erythrocyte membrane, Biochemistry, Biology

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Existence of Glucosaminyl Lactosyl Ceramide (Amino CTH-I) in Human Erythrocyte Membranes as a Possible Precursor of Blood Group-Active Glycolipids — Research Paper | ScholarLens