2010•CancersOpen access

Cancer Stem Cells in Pancreatic Cancer

Qi Bao, Yue Zhao, Andrea Renner, Hanno Nieß, Hendrik Seeliger, Karl‐Walter Jauch, Christiane J. Bruns

Abstract

Pancreatic cancer is an aggressive malignant solid tumor well-known by early metastasis, local invasion, resistance to standard chemo- and radiotherapy and poor prognosis. Increasing evidence indicates that pancreatic cancer is initiated and propagated by cancer stem cells (CSCs). Here we review the current research results regarding CSCs in pancreatic cancer and discuss the different markers identifying pancreatic CSCs. This review will focus on metastasis, microRNA regulation and anti-CSC therapy in pancreatic cancer.

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Key concepts: Pancreatic cancer, Cancer stem cell, Cancer, Metastasis, Medicine, Cancer research, Radiation therapy, Oncology