OVARIAN STIMULATION TEST USING HUMAN MENOPAUSAL GONADOTROPHIN (HMG)

Summary. A stimulation test involving the administration of hmg has been used to investigate ovarian function in patients with amenorrhoea. A total of twenty-seven subjects was studied and two different test designs were employed. It was concluded that good results were obtained even when the hmg injections were not followed by hcg. With the standard procedure which was eventually adopted, fifteen out of sixteen patients responded satisfactorily. The ovarian response to hmg was greater in patients in whom pre-treatment gonadotrophin levels were within the normal range. For the same dosage of fsh, hmg o was more potent and had a longer duration of effect than hmg s. hmg o sometimes provoked luteal stimulation but this effect was not noted with hmg s. It is presumed that this difference between the two preparations results from their varying lh content.