2003•Antimicrobial Agents and ChemotherapyOpen access

Lack of Synergy of Erythromycin Combined with Penicillin or Cefotaxime against Streptococcus pneumoniae In Vitro

Eugene Lin, Ronald J. Stanek, Maurice A. Mufson

Abstract

We investigated a possible synergistic effect of a macrolide and beta-lactams against Streptococcus pneumoniae strains with different resistance profiles. Checkerboard and time-kill assays of erythromycin combined with penicillin or cefotaxime essentially showed indifference, suggesting that these antibiotics in combinations in vitro act substantially as individuals in their activity against S. pneumoniae.

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Key concepts: Cefotaxime, Streptococcus pneumoniae, Erythromycin, Penicillin, Microbiology, Antibiotics, In vitro, Checkerboard