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Comparison of transforming growth factor-beta/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions.

Miki Tsujita‐Kyutoku, Norihisa Uehara, Yoichiro Matsuoka, Shigeo Kyutoku, Yutaka Ogawa, Airo Tsubura

Abstract

BACKGROUND: Keloids are benign proliferations of fibroblasts, but their exact etiology and molecular pathogenesis are unknown. MATERIALS AND METHODS: Fibroblasts were isolated from the central and peripheral regions of keloids, and the growth behavior and molecular characteristics of the keloid fibroblasts were compared with those of age-adjusted normal dermal fibroblasts. RESULTS: Central (but not peripheral) keloid fibroblasts exhibited significantly increased growth and high levels of expression of transforming growth factor-beta (TGF-beta) receptor 1 and Smad 2/3. CONCLUSION: Proliferation of central keloid fibroblasts, which results in keloid formation, appears to mainly involve the TGF-beta/Smad pathway.

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Key concepts: Keloid, SMAD, Fibroblast, Extracellular matrix, Transforming growth factor, Wound healing, Cancer research, Pathogenesis