1991•Journal of General VirologyRequires access

Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds

Martin Gruenberger, D.C. Pevear, G. D. DIANA, Ernst Kuechler, Dieter Blaas

Abstract

Four WIN compounds with anti-picornavirus activities were tested for their ability to stabilize human rhinovirus serotype 2 (HRV-2) against low pH-induced conformational changes in vitro, as determined by specific immunoprecipitation. These results were compared to the minimal inhibitory concentration (MIC) as measured in a plaque reduction assay. A direct relationship was observed between the concentration of the compound that prevented the low pH-induced conformational changes and the MIC, indicating that stabilization is an important element in the mode of action of these drugs against HRV-2.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 46 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Rhinovirus, Picornavirus, Serotype, In vitro, Biology, Conformational change, Virology, Immunoprecipitation