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1969•Journal of Radiation ResearchOpen access

The Mortality and Body Weight Response of Male Wistar Rats in the Lethal X-ray Dose Range

S Tsuchihashi, Yoshikazu Enomoto, Takeshi Yamada, Wataru Nakamura, Hideo Etō

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Abstract

Experiments were conducted to determine the LD50/30 of Wistar strain male rats, aged 72 to 112 days, bred in National Institute of Radiological Sciences. The animals were irradiated at eight exposure levels between 600 and 90O R of X-rays at rate of 23.5 R/min. Probit analysis of mortality data yielded an LD50/30 of 761.6±31.8 R. The body weight of the animals was decreased gradually after irradiation, reaching a minimum value at 4th day after the exposure. The body weight of 30-day survivors shows the second minimum value at 18-21 st day after irradiation.

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Experiments were conducted to determine the LD50/30 of Wistar strain male rats, aged 72 to 112 days, bred in National Institute of Radiological Sciences. The animals were irradiated at eight exposure levels between 600 and 90O R of X-rays at rate of 23.5 R/min. Probit analysis of mortality data yielded an LD50/30 of 761.6±31.8 R. The body weight of the animals was decreased gradually after irradiation, reaching a minimum value at 4th day after the exposure. The body weight of 30-day survivors shows the second minimum value at 18-21 st day after irradiation.

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Available abstract

Experiments were conducted to determine the LD50/30 of Wistar strain male rats, aged 72 to 112 days, bred in National Institute of Radiological Sciences. The animals were irradiated at eight exposure levels between 600 and 90O R of X-rays at rate of 23.5 R/min. Probit analysis of mortality data yielded an LD50/30 of 761.6±31.8 R. The body weight of the animals was decreased gradually after irradiation, reaching a minimum value at 4th day after the exposure. The body weight of 30-day survivors shows the second minimum value at 18-21 st day after irradiation.

Key concepts: Body weight, Lethal dose, Dose rate, Irradiation, Animal science, Toxicology, Physiology, Median lethal dose

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