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2013•Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical SciencesOpen access

APPLICATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS AS DRUG DELIVERY SYSTEMS

Hamidreza Kelidari, Jafar Âkbari, Saeidi Majid

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Abstract

Nowadays solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been investigated as carrier systems for many applications. SLNs consist of pure solid lipids, while NLCs are made of a solid matrix that entraps liquid lipid nano-compartments. These systems revealed several advantages compared to other colloidal carrier systems. They provide a controlled drug release and an increase in chemical stability of the incorporated drugs. Moreover, they are safe carriers which can be produced easily in a large scale. This paper reviews the commonly used materials, production techniques, characterization, and physical stability of these systems.

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What this paper is about

Nowadays solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been investigated as carrier systems for many applications. SLNs consist of pure solid lipids, while NLCs are made of a solid matrix that entraps liquid lipid nano-compartments. These systems revealed several advantages compared to other colloidal carrier systems. They provide a controlled drug release and an increase in chemical stability of the incorporated drugs. Moreover, they are safe carriers which can be produced easily in a large scale. This paper reviews the commonly used materials, production techniques, characterization, and physical stability of these systems.

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Available abstract

Nowadays solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been investigated as carrier systems for many applications. SLNs consist of pure solid lipids, while NLCs are made of a solid matrix that entraps liquid lipid nano-compartments. These systems revealed several advantages compared to other colloidal carrier systems. They provide a controlled drug release and an increase in chemical stability of the incorporated drugs. Moreover, they are safe carriers which can be produced easily in a large scale. This paper reviews the commonly used materials, production techniques, characterization, and physical stability of these systems.

Key concepts: Solid lipid nanoparticle, Drug delivery, Drug carrier, Carrier system, Nanotechnology, Nanoparticle, Characterization (materials science), Medicine

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APPLICATION AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS AS DRUG DELIVERY SYSTEMS — Research Paper | ScholarLens