2013•Antimicrobial Agents and ChemotherapyOpen access

ComparativeIn VitroActivities of SMT19969, a New Antimicrobial Agent, against 162 Strains from 35 Less Frequently Recovered Intestinal Clostridium Species: Implications for Clostridium difficile Recurrence

Ellie J. C. Goldstein, Diane M. Citron, Kerin L. Tyrrell

Abstract

We determined the comparative activity of SMT19969 (SMT) against 162 strains representing 35 well-characterized Clostridium species in clusters I to XIX and 13 Clostridium species that had no 16S rRNA match. SMT MICs ranged from 0.06 to >512 μg/ml and were not species related. SMT might have less impact on normal gut microbiota than other Clostridium difficile infection (CDI) antimicrobials.

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Key concepts: Clostridium difficile, Clostridium, Clostridiales, Microbiology, Clostridiaceae, Biology, Antimicrobial, 16S ribosomal RNA