ScholarLens Back to search
1986•MicrobiologyOpen access

In Streptococcus faecium Penicillin-binding Protein 5 Alone Is Sufficient for Growth at Sub-maximal But Not at Maximal Rate

Pietro Canepari, M. D. M. LLEO, Giuseppe Cornaglia, Roberto Fontana, G Satta

Open full text 42 citations

Abstract

In Streptococcus faecium inhibition by both benzylpenicillin and cefotaxime of cells growing at maximal and at reduced rates was associated with saturation of different penicillin-binding proteins. Cells growing at reduced rates were not inhibited by benzylpenicillin concentrations that saturated all penicillin-binding proteins except penicillin-binding protein 5, but did stop growing when this protein was saturated.

Open-access reader

About this research paper

What this paper is about

In Streptococcus faecium inhibition by both benzylpenicillin and cefotaxime of cells growing at maximal and at reduced rates was associated with saturation of different penicillin-binding proteins. Cells growing at reduced rates were not inhibited by benzylpenicillin concentrations that saturated all penicillin-binding proteins except penicillin-binding protein 5, but did stop growing when this protein was saturated.

Why it matters

OpenAlex reports 42 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

In Streptococcus faecium inhibition by both benzylpenicillin and cefotaxime of cells growing at maximal and at reduced rates was associated with saturation of different penicillin-binding proteins. Cells growing at reduced rates were not inhibited by benzylpenicillin concentrations that saturated all penicillin-binding proteins except penicillin-binding protein 5, but did stop growing when this protein was saturated.

Key concepts: Benzylpenicillin, Penicillin, Penicillin binding proteins, Cefotaxime, Microbiology, Streptococcus, Chemistry, Saturation (graph theory)

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
In Streptococcus faecium Penicillin-binding Protein 5 Alone Is Sufficient for Growth at Sub-maximal But Not at Maximal Rate — Research Paper | ScholarLens