2011•Molecular PharmacologyRequires access

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line

Maki Hasegawa, Yury Kapelyukh, Harunobu Tahara, Jost Seibler, Anja Rode, Sylvia Krueger, Dongtao N. Lee, C. Roland Wolf, Nico Scheer

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Key concepts: Pregnane X receptor, CYP3A4, CYP3A, Constitutive androstane receptor, Drug metabolism, Cytochrome P450, Humanized mouse, Biology

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Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse Line — Research Paper | ScholarLens