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2001•中醫藥雜誌Requires access

EFFECT OF CURCUMIN ON THEOPHYLLINE PHARMACOKINETICS IN RABBITS

Hui Ching, Shang-Yuan Tsai, Su‐Lan Hsiu, Pingping Wu, Pei-Dawn Lee Chao

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Abstract

Theophylline is a widely used bronchodilator with narrow therapeutic index and undergoes extensive metabolism by CYP1A2. Curcumin is a natural polyphenol with various beneficial biological activities and was shown to be a potent inhibitor of CYP 1A2. The purpose of this study was to investigate the effect of curcumin on the pharmacokinetics of theophylline in rabbits. The result showed that curcumin only significantly increased the absorption half-life of theophylline from 0.20±0.02 h to 0.36±0.05 h, other pharmacokinetic parameters were not affected. It indicated that coadministration of curcumin delayed the onset of theophylline but would not result in the acute intoxication of theophylline.

About this research paper

What this paper is about

Theophylline is a widely used bronchodilator with narrow therapeutic index and undergoes extensive metabolism by CYP1A2. Curcumin is a natural polyphenol with various beneficial biological activities and was shown to be a potent inhibitor of CYP 1A2. The purpose of this study was to investigate the effect of curcumin on the pharmacokinetics of theophylline in rabbits. The result showed that curcumin only significantly increased the absorption half-life of theophylline from 0.20±0.02 h to 0.36±0.05 h, other pharmacokinetic parameters were not affected. It indicated that coadministration of curcumin delayed the onset of theophylline but would not result in the acute intoxication of theophylline.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Theophylline is a widely used bronchodilator with narrow therapeutic index and undergoes extensive metabolism by CYP1A2. Curcumin is a natural polyphenol with various beneficial biological activities and was shown to be a potent inhibitor of CYP 1A2. The purpose of this study was to investigate the effect of curcumin on the pharmacokinetics of theophylline in rabbits. The result showed that curcumin only significantly increased the absorption half-life of theophylline from 0.20±0.02 h to 0.36±0.05 h, other pharmacokinetic parameters were not affected. It indicated that coadministration of curcumin delayed the onset of theophylline but would not result in the acute intoxication of theophylline.

Key concepts: Theophylline, Curcumin, Pharmacokinetics, Pharmacology, CYP1A2, Bronchodilator, Chemistry, Therapeutic index

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