2006•Chemical and Pharmaceutical BulletinOpen access
Synthesis and Peptidyl-Prolyl Isomerase Inhibitory Activity of Quinoxalines as Ligands of Cyclophilin A
Feng Wang, Jing Chen, Xuejun Liu, Xu Shen, Xuchang He, Hualiang Jiang, Donglu Bai
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Abstract
In search of small molecule compounds as the ligands of cyclophilin A, a series of quinoxalines were prepared, and their K(d) values of cyclophilin A and IC50 values for peptidyl-prolyl isomerase activity of cyclophilin A were tested. The results suggest that some quinoxalines are promising ligands of cyclophilin A.
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