2004•PhysiologyRequires access

A Nonconventional Look at Ionic Fluxes in the Skin: Lessons From Genetically Modified Mice

Marjorie Guitard, Céline Leyvraz, Edith Hümmler

Abstract

The mammalian, highly amiloride-sensitive epithelial sodium channel (ENaC) is member of the degenerin/ENaC superfamily of ion channels known to be implicated in sodium homeostasis, mechanosensation, and mechanoperception. A novel role for ENaC implicated in differentiation processes in skin reshapes our current view of this ancient transmembrane channel protein.

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Key concepts: Epithelial sodium channel, Amiloride, Mechanosensation, Ion channel, Transmembrane protein, Sodium, SUPERFAMILY, Chemistry