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2007•Nucleic Acids Symposium SeriesOpen access

Design of peptide nucleic acid by introduction of carbohydrate on lysine linker.

Akinori Noguchi, Hilal Surmuş Asan

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Abstract

We synthesized "cartridge" type monomer involving mannose unit on lysine as a linker and additionally inserted it to peptide nucleic acid (PNA) oligomer. Advantage of this procedure is that functional molecule could be easily introduced into anywhere position of PNA without sacrificing basepairs, although such insertion lowered stability of the duplex with DNA.

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We synthesized "cartridge" type monomer involving mannose unit on lysine as a linker and additionally inserted it to peptide nucleic acid (PNA) oligomer. Advantage of this procedure is that functional molecule could be easily introduced into anywhere position of PNA without sacrificing basepairs, although such insertion lowered stability of the duplex with DNA.

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Available abstract

We synthesized "cartridge" type monomer involving mannose unit on lysine as a linker and additionally inserted it to peptide nucleic acid (PNA) oligomer. Advantage of this procedure is that functional molecule could be easily introduced into anywhere position of PNA without sacrificing basepairs, although such insertion lowered stability of the duplex with DNA.

Key concepts: Linker, Peptide nucleic acid, Nucleic acid, Monomer, Oligomer, Lysine, Chemistry, DNA

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