2010•Horticultural Science and TechnologyRequires access
Biological Activities of Coreopsis tinctoria Nutt. Flower Extracts
In Guk Hwang, Hyun Young Kim, So Lim Shin, Cheol Hee Lee, Junsoo Lee, Keum Il Jang, Heon Sang Jeong
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Abstract
This study was conducted to evaluate the antioxidant activity, Angiotensin I Converting Enzyme (ACE) inhibitory activity, -glucosidase inhibitory activity, nitrate synthesis inhibitory activity, and antiproliferation inhibitory effect on ethanol extract and its solvent fractions of Coreopsis tinctoria Nutt. Ethyl acetate fraction was the strongest at 1,1-diphenyl-2-picryl hydrazyl (DPPH) (IC50 = 0.100 mg·mL -1 ) and 2,2'-Azino-bis- (3-ethylbenozothiazoline-6-sulfonic acid) (ABTS) (15.785 mg AA eq·10 mg -1 ) radical scavenging activity, ACE (40.96% at 1 mg·mL -1 ), and -glucosidase (IC50 = 0.125 mg·mL -1 ) inhibitory effect among the solvent fractions. Nitrate synthesis inhibitory activity of ethanol extract, chloroform fraction, and ethyl acetate fraction effectively inhibited NO formation in a dose-dependent manner without the cytotoxic effect. Ethanol extract and its solvent fractions inhibited growth of HCT-116 colon cancer cells in a dose-dependent manner. n-Hexane fraction showed the highest antiproliferation inhibitory effect of 0.041 mg·mL -1 among fractions.