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Mammary neoplasia in Sprague-Dawley or Long-Evans rats after in vitro 7, 12-dimethylbenz(alpha) anthracene.

Raya Brown, Claire J. Shellabarger

Abstract

Summary Long-Evans female rats show a smaller mammary neoplastic response than do Sprague-Dawley females to 7,12-dimethylbenz(α)anthracene (DMBA) applied directly to mammary tissue in vitro when the excised mammary tissue is grafted back into the animal from which it came. Long-Evans rats also give a smaller mammary neoplastic response to DMBA administrated by stomach tube. It was suggested that the difference in the mammary neoplastic response to DMBA observed in the 2 strains depends upon strain differences that act after the initial DMBA-mammary tissue interaction.

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Key concepts: DMBA, 7,12-Dimethylbenz[a]anthracene, Mammary tumor, Anthracene, Internal medicine, Mammary gland, Endocrinology, In vitro